Dr. Sushil Paudyal is Assistant Professor of Dairy Science at Texas A&M and an outstanding dairy researcher. Dr. Paudyal has a great interest in both nutrition and health issues in dairy cows, but he also likes to study these kinds of interactions in organic dairy cows. Sushil and I have been teaming up over the past couple of years on a few projects and we are starting one this fall (October 2024) that is very interesting.
In partnership with Kent Nutrition Group, we’re conducting a feeding trial involving a Humic Acid Substance, specifically Menefeed MFG 150, with pens of lactating organic dairy cows. We’ll compare a group that receives Menefeed MFG 150 to a non-fed group and then switch the groups for another phase of the study. This “crossover” design will help us better understand how the supplement impacts these animals.
Our focus will be on three main areas:
Milk Yield and Composition: We’ll monitor how Menefeed MFG 150 affects both the quantity of milk produced and its quality, including components like fat and protein content.
Health Status: By analyzing blood serum tests, we aim to understand how this humic acid substance might influence cow health—looking at factors like immune function and overall vitality.
Rumination and Milk Conductivity: Using sensors, we plan to track rumination time and milk conductivity, which can give insights into digestive efficiency and udder health.
Menefeed MFG 150 is OMRI-listed, meaning it meets the requirements for use in organic systems, which is crucial for our organic dairy trial. The humic substances used in Menefeed MFG 150 are derived from Freshwater Reed-Sedge Peat, a mined product that undergoes mechanical processing to become suitable for animal feeding.
What are humic substances?
Humic substances are organic compounds that come from the decomposition of plant and microbial materials. You may already be familiar with humic and fulvic acids from their use in improving soil health or as foliar plant sprays (link to humic and fulvic acid info for crops). These substances have been shown to have many beneficial properties, although their exact mechanisms can sometimes be mysterious. Research has shown mixed results—sometimes they provide a clear benefit, and other times they don’t—but the potential benefits keep us intrigued.
In dairy cows, recent studies suggest that humic substances like Menefeed MFG 150 may improve rumen fermentation, enhance nutrient utilization, and even support the immune system. If these effects prove true, and if we see an increase in milk production, this trial could lead to a win-win situation for organic dairy farmers, helping them achieve greater production while maintaining cow health.
(This article first appeared in “Texas Dairy Matters” and has since been published in Texas Ag and Dairy Review. I have had an opportunity to work with some of these technologies and these researchers on an organic dairy investigating the potential to improve both mastitis control and long-term animal health. Bob Whitney)
Non-Antibiotic Management of Mastitis in Dairy Cattle
1 Graduate Research Assistant 2 Assistant Professor. Department of Animal Sciences, Texas A&M AgriLife Extension Service, The Texas A&M University System
Mastitis is a common and costly disease affecting dairy cattle worldwide. It is characterized by inflammation of the mammary gland, typically caused by bacterial infection. Mastitis is typically managed on dairy herds with intramammary antibiotics. However, not all mastitis events respond to treatment with antibiotics, depending on the pathogen associated with the disease event and cow level factors. In addition, prudent and appropriate use of antibiotics is an essential step in achieving antimicrobial stewardship in dairy farms. In some management systems such as organic systems, the use of antibiotics is restricted (USDA, 2017). This presents the need to explore options to manage mastitis without the use of antibiotics.
In this article, we discuss. some strategies currently being evaluated by our group to manage mastitis events.
A) Acoustic pulse technology:
Acoustic pulse technology, APT, has emerged as a promising non-antibiotic therapy for managing mastitis in dairy cattle. Specifically adapted for treating mastitis, APT uses repeated projectile collisions with an anvil connected to the treatment head. These collisions generate low-incidence shockwaves or acoustic pulses that are transferred non-invasively to the affected mammary gland tissues. Similarly to ultrasound therapy, ATP uses sound waves to deliver energy. However, APT delivers lower-frequency sound waves that can penetrate deeper into tissues compared to ultrasound therapy. The therapeutic effects of APT include promoting recovery, reducing inflammation, and potentially improving blood flow and immune responses (Leitner et al., 2021). Recent studies have shown positive outcomes, such as increased recovery rates, reduced culling and additional milk yield in APT-treated cows compared to controls (Blum et al., 2023). This innovative approach offers an alternative to antibiotics, contributing to udder health and overall dairy cow welfare.
B) Cold laser therapy:
Cold laser therapy, also known as low-level laser therapy, has been explored as a potential non-antibiotic treatment for mastitis in dairy cattle. Cold laser therapy is currently used by many veterinarians as an alternative therapy approach to manage inflammation in small and large animals, including horses. This technology works on the principle of “photobiomodulation,” which refers to a therapeutic technique that uses light energy to stimulate cellular processes. In the context of dairy cattle, photobiomodulation has gained attention for its potential benefits in various aspects of herd health and productivity. There are reports of this technology used to promote wound healing and tissue repair. Photobiomodulation can accelerate wound healing and tissue repair by promoting cellular metabolism and enhancing blood flow. The technology can also help with pain management as the anti-inflammatory effects of photobiomodulation can help alleviate pain and discomfort. It has particularly been useful for managing conditions like lameness or joint inflammation (Gard et al., 2017).
Photobiomodulation has been explored as an adjunctive therapy for mastitis treatment. By reducing inflammation and promoting immune responses, it may aid in faster recovery. Light-emitting diodes, LEDs, or lasers are used to deliver specific wavelengths of light to targeted areas for a specific duration. Treatment protocols vary, but sessions are typically short and non-invasive. Although research is ongoing by our group, the results have indicated potential benefits. In à separate study, the laser irradiation resulted in a 16.6% increase in recovery, indicated by regression of signs of inflammation and a decrease in the somatic cell counts. Supportive treatment with laser irradiation increased recovery rates by 24.2% (Malinowski, et al., 2019). However, further studies are needed to establish its efficacy by evaluating optimal duration and wavelength combination for mastitis and somatic cell count management.
C) Plant molecule-based compounds:
One of the new tools for mastitis management that is getting attention is called antibiofilm compounds derived from plant molecule-based a non-antibiotic therapy for compounds. Mastitis-causing bacteria form and maintain biofilm through the process of quorum sensing. Bacteria produce biofilms as a survival strategy, especially in challenging environments. Biofilm protects the bacteria as a shield preventing immune cells from directly reaching the bacteria. The plant-based molecules use quorum sensing science to disrupt communication between selected mastitis-causing bacteria (Herrema et al., 2023). The components can block bacterial communication and influence their behavior such as biofilm formation. This process is called quorum quenching or quorum sensing inhibiting. In bacteria, the formation of biofilms is controlled by quorum sensing, QS, signaling genes and their products. Various inhibitors/compounds can disturb the QS signaling cascade and are used as an alternative therapy to optimize biofilm-related challenges. Reducing bacterial QS signaling by proprietarily selected plant molecules is possible because they possess inhibitory activity against bacterial and fungal biofilms. There are claims this technology promotes overall herd health and longevity of cows.
(The plant molecule-based compounds currently being evaluated are produced by AHV International. Some organic dairy producers are reporting varied success with these treatments, but more work is being done to evaluate their use. Bob Whitney)
References:
Blum, S.E., Krifuks, O., Weisblith, L., Fleker, M., Lavon, Y., Zuckerman, A., Hefer, Y., Goldhor, O., Gilad, D., Schcolnic, T. and Leitner, G., 2023. Evaluation of acoustic pulse technology as a non-antibiotic therapy for intramammary infections: Assessing bacterial cure biofilm vs. recovery from inflammation. Frontiers in Veterinary Science, 10, p.1079269.
Gard, J. 2017. Laser Therapy in Food-Animal Practice. Laser Therapy in Veterinary Medicine: Photobiomodulation, 423-430.
Herrema, F., Bieleman, H., Hoekstra, M. and Gomes, J., 2023. Longevity and Milk Production Improvement in Dairy Cows Using Plant-Derived Products. J Vet Heal Sci, 4: 128-140.
Leitner, G., Papirov, E., Gilad, D., Haran, D., Arkin, O., Zuckerman, A. and Lavon, Y., 2021. New treatment option for clinical and subclinical mastitis in dairy cows using Acoustic Pulse Technology (APT). Dairy, 2: 256-269.
Malinowski, E., Krumrych, W. and Markiewicz, H., 2019. The effect of low intensity laser irradiation of inflamed udders on the efficacy of antibiotic treatment of clinical mastitis in dairy cows. Veterinaria italiana, 55: 253-260.
USDA, AMS 2017. National Organic Program (NOP); Organic Livestock. and Poultry Practices. A rule by the Agricultural Marketing Service. The Federal Register.
Texas A&M AgriLife Organic 